How can dietary or lifestyle changes extend saffron's effectiveness?

Dietary and lifestyle changes can support and extend the effectiveness of saffron supplements for eye health, particularly in age-related macular degeneration (AMD), by enhancing antioxidant protection, reducing inflammation, and maintaining overall retinal health.

Key Dietary and Lifestyle Factors

• Antioxidant-rich diet: Eating foods high in carotenoids like lutein and zeaxanthin (found in dark leafy greens such as spinach, kale, and collard greens) supports macular pigment and helps protect retina cells from oxidative stress, complementing saffron's antioxidant effects.

• Omega-3 fatty acids: Regular intake of omega-3s from oily fish (salmon, mackerel, trout) or supplements reduces inflammation and supports retinal cell function.

• Vitamins and minerals: Vitamins C, E, zinc, and copper are recommended to help slow AMD progression by protecting eye cells from damage; these nutrients work synergistically with saffron’s antioxidant properties.

• Low glycemic index (GI) foods: Consuming low-GI carbohydrates (whole grains, legumes, fruits, and vegetables) helps reduce risk factors associated with AMD progression, supporting eye health maintenance.

• Avoid smoking: Smoking increases oxidative stress and accelerates retinal damage, so cessation strengthens saffron’s protective effects on the eyes.

• Physical activity: Regular exercise improves circulation and reduces many systemic risk factors associated with AMD and eye aging.

• Manage overall health: Controlling blood sugar, blood pressure, and cardiovascular health supports optimal eye function, potentially enhancing saffron’s benefits.

Summary

Combining saffron supplementation with a nutrient-rich diet high in carotenoids and antioxidants, omega-3 fatty acids, low-GI foods, plus healthy lifestyle habits such as not smoking and regular exercise, can extend and amplify saffron’s effectiveness for maintaining and improving eye health in AMD.

PMID: 30986936

PMID: 35548173