Yes, there are several long-term clinical studies on saffron's sustained benefits for eye health, especially in age-related macular degeneration (AMD). These studies consistently demonstrate that daily saffron supplementation (typically 20–30 mg/day) leads to measurable improvements in retinal function and visual acuity, with benefits sustained as long as supplementation continues—sometimes for 12–24 months or more. PMID: 38485112
Evidence from Long-Term Studies
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A European open-label extension trial followed adults with mild/moderate AMD for 12 months while taking 20 mg saffron daily. Results showed sustained improvements in electroretinogram (ERG) markers and stabilized visual acuity, with no major safety issues. Benefits included higher response density in key retinal areas—suggesting lasting neuroprotection and functional gain with ongoing use.
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An Italian clinical trial tracked patients for up to 14 months, showing improved macular flicker sensitivity and visual acuity after 3 months, which remained stable for the study duration. Effects persisted as long as supplementation continued.
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Additional studies and reviews highlight benefits maintained for at least 1–2 years, with some patients experiencing no further AMD progression during this period compared to those using only standard AREDS supplements.
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A literature review of nine clinical studies confirmed that longer-term saffron supplementation yields cumulative and sustained benefits in AMD, particularly for those at early stages of the disease. PMID: 38485112 & Reference 2
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