How long do saffron benefits last after stopping treatment?

The benefits of saffron supplementation for macular degeneration generally diminish within weeks to a few months after stopping treatment, with improvements in retinal function and vision often reversing if supplementation is discontinued. (PMCID: PMC5342880)

What Happens After Stopping Saffron

• Research shows that visual improvements and gains in retinal function do not persist long-term after stopping saffron supplementation.

• Benefits, such as enhanced visual acuity and retinal sensitivity, may begin to fade within several weeks, and most patients gradually return to baseline within 1–3 months of discontinuation.

• Ongoing or sustained supplementation is recommended for lasting benefits, especially for chronic conditions like AMD. PMCID: PMC10941132

Supporting Evidence

• A review of six studies found that stopping saffron led to reversal of gains, with eyes returning to pre-treatment status within a few months.

• Most trials with follow-up periods indicate benefits are maintained only while supplementation is ongoing, emphasizing the need for continued use.

• No studies suggest permanent improvements after cessation; AMD’s progressive nature requires ongoing intervention. PMCID: PMC10941132 & (PMCID: PMC5342880)

Summary

Saffron’s benefits for AMD typically do not last long after stopping treatment; continued supplementation is needed to maintain improvements in vision and retinal health.  (PMCID: PMC5342880)